Anti-anxiety Activity of Citrus paradisi var. duncan Extracts in Swiss Albino Mice -A Preclinical Study 


Anti-anxiety Activity of Citrus paradisi var. duncan Extracts in Swiss Albino Mice -A Preclinical Study 

Vikas Gupta1*, Parveen Bansal1, Junaid Niazi2, Kamlesh Kohli3, Pankaj Ghaiye4JHMR-CODE

1University Centre of Excellence in Research, BFUHS, Faridkot, India
2Department of Pharmaceutical Chemistry, Bahra Institute of Pharmacy, Patiala, India
3Department of Pharmacology, Guru Gobind Singh Medical College, BFUHS, Faridkot, India
4Department of Pharmaceutics, ACPTE, Sangrur, India

Review method: Single-blind; Peer reviewer comments: 1.


Background: Fragrances from aromatic oils of Citrus have been particularly attributed with mood enhancing properties by aroma therapists. Volatile oils are available in very small amounts hence authors intend to establish antianxiety activity of leaf extracts that can be made available for commercial purposes. Objectives: The present study was designed to authenticate the already established anti-anxiety activity (by using elevated plus maze model) of various extracts of the leaves of Citrus paradisi var. Duncan by authors using different animal models. Methods: Swiss Albino mice were treated with different doses of the leaf extracts (50, 100, 200 and 400 mg / kg p.o.) and Diazepam (2mg/kg, p.o) was used as a positive control. Antianxiety activity was determined using Y maze model, light dark model and hole board methods. Results: Results of study show that methanol extract in higher doses (100, 200, 400 mg/kg) possesses marked anti anxiety activity and was comparable to the effect produced by diazepam. Conclusion: The plant can be developed as a commercial source of anxiolytic agent. Further studies are in-process to isolate the active constituent responsible for this activity and mechanism of action.


Keywords: Anxiety, Grapefruit, Hole board test, Light dark model, Y maze

Free Full-text PDF


Terms of Use/Privacy Policy/ Disclaimer/ Other Policies:
You agree that by using our site, you have read, understood, and agreed to be bound by all of our terms of use/privacy policy/ disclaimer/ other policies (click here for details). This site cannot and does not contain professional advice. The information on this site is provided for general informational and educational purposes only and is not a substitute for professional advice. Accordingly, before taking any actions based upon such information, we encourage you to consult with the appropriate professionals. We do not provide any kind of professional advice. The use or reliance of any information contained on this site or our mobile application is solely at your own risk. Under no circumstance shall we have any liability to you for any loss or damage of any kind incurred as a result of the use of the site or our mobile application or reliance on any information provided on the site and our mobile application. We may publish articles without peer-review. Published articles of authors are open access. Authors hold the copyright and retain publishing rights without restrictions. Authors are solely responsible for their articles published in our journals. Publication of any information in authors’ articles does not constitute an endorsement by us. We make no representation or warranty of any kind, express or implied, regarding the accuracy, adequacy, validity, reliability, availability or completeness of any information that authors provided. more..


CC BY 4.0
This work and its PDF file(s) are licensed under a Creative Commons Attribution 4.0 International License.