Vitamin D is a hormone of great importance for vital body activities, as well as for the modulation of the immune system. Being acquired by food, but mainly by exposure to sunlight. Although reduced levels of vitamin D can cause problems related to bone mining, the excess of this is responsible for processes of intoxication. The present work aims to describe the levels of vitamin D of patients treated by a reference laboratory in the health district of Maceió-Al, describing the main affected population and producing a comparison of the levels in relation to social isolation. For this purpose, laboratory records were used considering the period from November 2019 to November 2020 and producing comparisons to sexes, age and analysis period of patients. In total, 1,025 vitamin D tests were performed, of which 27.4% of the patients were male and the other 82.6% were female. During the defined periods, greater numbers of exams were performed in the period of social relaxation. During the analyzed period, higher levels of deficiency were observed in adolescent and, mainly, elderly patients, compared to sexes, women had a higher level of deficiency and the highest levels of vitamin D deficiency during the period of social isolation.
THE BENEFITS OF FOLLOW-UP BY THE MULTIDISCIPLINARY TEAM IN HEALTH FOR PEOPLE WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Objective: Discuss the benefits of monitoring by a multidisciplinary health team for the treatment of patients with systemic lupus erythematosus. Methods: The research proposal is based on a review of bibliographic references, with a source of synthesizing results obtained through secondary research on the theme, in a methodical and orderly manner, seeking to contribute to the knowledge on the proposed subject. Results: Through a thorough analysis of theoretical references, 30 scientific articles were selected that alluded to the systemic lupus erythematosus pathology. Systemic lupus is characterized by articular, cutaneous, renal, vascular, serous, nervous manifestations, decreased mobility, muscle strength, physical conditioning and quality of sleep, increased joint stiffness, pain and fatigue and can cause, even depression, obesity and / or malnutrition, impacting quality of life. Conclusion: The research presented relevant results on the monitoring by the multidisciplinary health team for the treatment of patients diagnosed with systemic lupus erythematosus, presenting data that justify the construction of a structured support network, which will contribute to the therapy of this patient, providing well-being and improvements in quality of life. Taking into account the situation that the pathology presents, these data are at least disturbing. These bases made it possible to expand the discernment on the subject, opening a succession of discussions to find proposals and resolutions that can corroborate with the treatment of people diagnosed with chronic diseases such as SLE.
Yangambin, a lignan isolated from the leaves of Ocotea duckei Vattimo-Gil, has several pharmacological activities described in literature. However, few information about its toxicity has been reported. Red cells represent about 90% of blood cells and have interesting structural and molecular characteristics as experimental models in toxicological studies. Thus, the aim of this study was to evaluate the hemolytic action of yangambin in sheep blood. The hemolysis assay was performed at concentrations of 50, 25 and 12.5 µg/mL of yangambin in triplicate and hemolysis percentage was defined through the absorbance resulting from the test concentrations compared to the positive control. The results showed that yangambin did not cause hemolysis at the concentrations tested, therefore it did not cause damage to the plasma membrane of sheep erythrocytes.
ANTIDEPRESSANT-LIKE EFFECT OF DIMETHYL FUMARATE AND ASTROCYTE CHANGES IN HIPPOCAMPUS OF MICE SUBMMITED TO MODEL OF DEPRESSION
Introduction: Depression is a psychiatric condition of high prevalence worldwide and is associated with inflammation. Dimethyl fumarate, used to treat psoriasis and multiple sclerosis, has demonstrated an anti-inflammatory effect. Objective: To evaluate the effect of dimethyl fumarate on depression, through the immobility time in the forced swim test, and on astrocyte proliferation, through the expression of glial fibrillary acidic protein in the hippocampus of mice submitted to Chronic Unpredictable Mild Stress- induced model of depression. Methods: Male mice were divided into three groups: control(1), stressed(2), stressed+dimethyl fumarate (3). Groups 2 and 3 were subjected to 28 days of exposure to unpredictably applied stressors. From the 14th day, group 3 was treated with dimethyl fumarate (oral). At the end, the hippocampus was removed to determination of glial fibrillary acidic protein expression by immunofluorescence. Results: The immobility time was increased by chronic stress compared to the control and the treatment with dimethyl fumarate decreased this parameter, compared to the stressed group [F (9, 92) = 6,460; 1vs2: p
Objective: To analyze hospital mortality, in urgency character, due to external causes in Brazil. Methods: This is a transversal, descriptive and quantitative study performed with secondary data from the Sistema de Informação Hospitalar do Sistema Único de Saúde (SIH/SUS). For data selection, external cause mortality from 2009 to 2019 was used, considering “urgency” as attendance character in the age range from 20 to 80 years or older. Besides, the variables sex, causes and regions were analyzed. Absolute and relative frequencies were calculated using Microsoft Excel® 2016 software. Results: It is observed that 67.60% (n=214,711) of deaths were due to external causes in urgency character attendance, since 71.03% (n= 150,123) were male and 28.97% (n= 64,588), female. The main deaths causes were: other external causes of accidental injuries 68.30% (n= 120,306), traffic acidentes, with 21.55% (n= 37,967) and aggressions, 10.15% (n= 17,879). As for the distribution of percentages between regions, the Southeast presented 44, 41% (n= 95,360), followed by Northeast region, with 25,00% (n= 53694); South, 16,93% (n= 36,352); Midwest, 7,12% (n= 15,294) and North, 6,52% (=14011). Conclusion: The prevalence of mortality from major external causes in urgency character presented a higher quantitative in males aged 20 to 80 years or older, and, among regions, Southeast, Northeast and South obtained a higher percentage of mortality compared to North and Midwest. Such knowledge allows the construction of possible public policies to reduce high hospital mortality rates.
Considerations On Human Immunodeficiency Virus (Hiv) Disease Mortality In Brazil Between 1998 And 2017
Objective: Analyze mortality rates of the HIV disease in Brazil in a period of 20 years to determinate the behavior of the rates and the pattern of the victims. Methods: Data were collected from the Mortality Information System (SIM) by the Informatics Department of the Unified Health System (DATASUS) regarding deaths from HIV disease. All records and year of death, race, sex, age group, marital status and educational level of the person were considered. Results: In the 20 years studied, 232,274 deaths caused by the disease were recorded, an average of 11,613.7 (±1092.7) per year. White people represent 46.4%, followed by brown, 32.8%. Men are majority throughout the period, with 67.1% of records. People between 30 and 49 years old have the highest rates, 62.1% of deaths. Single people were majority, 61.1% of the total. As for education, people with up to 7 years of education correspond to 44% of deaths, while people with 12 years and more of education account for only 5.6%. Conclusions: White men, between 30 and 49 years old, single and with up to 7 years of schooling are, according to statistics, the most predisposed to die from the HIV disease. Especially from the data on education, it can be inferred that a higher level of education reduces the risks of death from the disease. Knowing this and the information about single people being more affected, the importance of sex education to early school years is recommended, as well as guidance in primary care.
Objective: To identify and describe in the current literature nursing interventions for patients affected by acute myocardial infarction. Methods: This is an integrative literature review conducted with materials indexed in the Virtual Health Library (VHL), in the databases: BDENF, LILACS and MEDLINE. Using as descriptors: Assistance, Myocardial Infarction and Nursing, mediated by the Boolean operator AND. The inclusion criteria were: full text, available, free of charge, in Portuguese, published in the chronicity of time from 2015 to 2020 and which responds to the research theme. Results: After crossing the descriptors, 1701 publications were identified, of which were included in review 10 that met the established criteria. 04 on the basis of LILACS, 01 on MEDLINE and 05 on BDENF, with the following percentages: 40%, 10%, 50%, respectively. Conclusion: It is necessary to continually update the team’s chest pain protocol and approaches to patients affected with acute myocardial infarction, as they present constant changes. Thus, aiming at improvements in interventions, quality assistance, minimization of adverse events and maximization of patient safety.
ASSOCIATION BETWEEN THE NUTRITIONAL STATUS AND RISK OF CARDIOVASCULAR DISEASES IN PATIENTS WITH RHEUMATOID ARTHRITIS ACCOMPANIED IN A REFERENCE CENTER IN A BRAZIL NORTHEAST REFERENCE CENTER
Introduction: Rheumatoid arthritis is an autoimmune and inflammatory disease, chronic and progressive, highly limiting, which can be aggravated when the nutritional status of this patient has dystrophy, so the body composition can influence the activity of this disease. Objective: To evaluate the association between nutritional status and the risk of cardiovascular disease in patients with rheumatoid arthritis in a reference center in the northeast. Material and Methods: Cross-sectional study carried out in a rheumatology clinic of a reference center in Northeast Brazil (Recife / PE) with patients with rheumatoid arthritis. Anthropometric measurements of weight and height were taken to assess the parameter of Body Mass Index (BMI). Measures of waist circumference (WC) and hip circumference (HC) were also taken to assess the parameters of waist-to-height ratio (WHtR) and waist-to-hip ratio (WHR), in order to investigate cardiovascular risk. The data were treated using the SPSS version 17.0 for Windows and Excel 2010. For the correlation analysis, the Chi-square test was used. The level of significance was set at 5%. The Bioethics Research Committee of the Instituto de Medicina Integral Professor Fernando Figueira (IMIP) approved the present study under nº 19163619.1.0000.5201 the participants signed the Informed Consent Form (ICF). Results: The study included 54 patients aged between 18 and 58 years old and a mean age of 47.26 years +/- 11.72 SD, 96.3% of whom were female. 42.9% of the studied population had obesity according to the Body Mass Index, followed by 35.7% with overweight. According to WC 52.6% had an increased risk for cardiovascular diseases. WHR and WHtR found risk for cardiovascular diseases in 64.9% and 84.5%, respectively. The association between BMI and WC was 0.000 p-value, whereas for BMI and WHR, WHtR was 0.176 p-value and 0.095 p-value respectively. Conclusions: There was a prevalence of obesity and overweight in patients…
Objective: Identify what is the burnout syndrome, how it affects professionals, what are its symptoms, what is the role of nursing in the face of this syndrome. Methods: This study is a bibliographic search, where information was extracted from the MEDILINE and SCIELO database. With the following descriptors: Alzheimer, Burnout and Elderly. Articles were selected between the years 2009 to 2013. We excluded all those that were not related to the proposed theme. Results: Burnout syndrome or professional exhaustion syndrome is a type of occupational and institutional stress, constituting one of the main occupational diseases in the world with a predilection for health professionals, education and assistance services. Inducing physical and psychological illness, compromising the lives of these professionals and the result of their work (COSTA, 2009). Bunourt’s syndrome affects caregivers in a very subtle and insidious way, the symptoms of this syndrome are diverse and can be divided into four levels: Physical health level, emotional level, psychic level, behavioral level (GUSMÃO et al., 2010). Nursing should contribute to preventive measures where it is possible to better understand how the syndrome starts and how it evolves over time, thus allowing it to act early in preventive actions (PEREIRA, 2013). Conclusion: There is a need to seek alternatives and expand studies related to minimizing factors that predispose to the appearance of burnout syndrome in caregivers of elderly people with Alzheimer’s.
Objective: Map the literature on mental illness in the general population and in health professionals during the Covid-19 pandemic. Methods: Research carried out within the VHL with the descriptors: covid AND mental health AND nursing professionals, in the database BDENF AND MEDLINE, filtering with the main subjects: Corona virus infections, nursing professionals, health personnel and mental health, using as exclusion criteria articles that were not in the Portuguese language and that were not within the theme of the study, including only articles published in the year 2020. Results: A total of 10 articles were found, all of them were analyzed. Among them, 9 (100%) dealt with the prevalence of mental illness in the general population, 5 (45%) in nurses, two (18%) in other health professionals and one (0.9%) in the general population and nurses. 15 symptoms of mental illness were identified. Conclusion: the Covid-19 pandemic triggered anxiety, depression, stress and post-traumatic stress disorders more frequently in the general population and health professionals. Women, students and nurses are among the most affected.