Recent Articles

  • FACT-CHECKING: AN IMPORTANT TOOL TO COMBAT FAKE NEWS ON HEALTH IN COVID-19 PANDEMIC

    Objective: To demonstrate the importance of Fact-Checking tools in combating health fake news in the COVID-19 pandemic. Methods: Quantitative descriptive study, conducted during the Sars-Cov-2 pandemic. Fake news were accounted and identified through the website chequeado.com, registered in the Agência Lupo and Aos Fatos checking platforms, belonging to the International Fact-Checking Network, an international understanding with recognized news verification methodologies. The registered news originated from the social media/networks Facebook, Whatsapp, Instagram, Twitter, and websites. They were later classified according to content in Conspiracy Theory, Prevention/Treatment/Cure, Authorities/Agency Measures, Situation of a city, state and country, Causes, Symptoms, Public Figure and False Context. Results: 529 fake news about coronavirus were obtained, of these 306 were from the Agência Lupo platform, and 223 from the Aos Fatos platform. A total of 99 (18.72%) fake news were about Conspiracy Theory 99 (18.72%) Authorities/Agency Measures and 98 (18.53%) False Context. As for the origin of fake news 382 (72.21%) were from Facebook and 67 (12.66%) from Whatsapp. Conclusion: The Fact-Checking tools in combating misinformation on social networks are important because they deny false news, unlikely allegations, and no justification related to the Covid-19 pandemic. These check sites alert social networks, policymakers, and the public to create measures that educate and protect the integrity and health of individuals and prevent them from falling victim to misinformation.

  • Territorialization As An Instrument For Expanding The Look Into The Territory: Experience Report

    Objective: To describe the experience of undergraduate students in the process of territorialization of some micro areas in Recife. Methods: Work based on academic practices of the discipline Occupational Therapy in Public Health – UFPE, in the 2nd semester of 2019, where students follow the professional performance in Primary Care. Among the activities carried out by the Extended Nucleus of Family Health and Primary Care, where the occupational therapist is inserted, there is the territorialization that, in this experience, took place in two meetings, specifically in some micro areas of the Health District VIII. Results: During the walk in the territory, the Community Health Agents presented the history of the community and reported that the community initially had a very industrialized profile. Subsequently, families began to establish themselves and take ownership of the place where they live until today, with several establishments such as schools, community spaces, squares, etc. that strengthen their identity The morbidities that most affect the elderly, young and male population are, respectively, chronic diseases, Sexually Transmitted Infections and infectious diseases. Territorialization is important in the process of planning interdisciplinary interventions and through it, the biopsychosocial dimensions are recognized and bring necessary discussions for all levels of care (COUTINHO, 2017). Conclusion: After the experience of Territorialization, it was possible to understand part of the complexity that is the territory, as well as to identify the main demands of the visited micro areas. Together with the NASF team, the occupational therapist can facilitate health education activities not only with the population itself, but also with professionals from the Family Health Unit.

  • MANDIBULAR OSTEONECROSIS RELATED TO THE USE OF BISPHOSPHONATE IN ONCOLOGY: CASE REPORT

    Objective: Evidence that the inflammation, infection, necrosis and pain present in osteonecrosis may be related to the use of bisphosphonates in oncology. Methods: It’s a clinical case report of mandibular osteonecrosis, female, 73 years old, treated and under medical and multiprofessional oncology follow-up, at the Oncology Center of the Oswaldo Cruz University Hospital of the University of Pernambuco, for control of invasive ductal carcinoma of breast (Anatomopathological115134) and bilateral bone and lung metastases. Currently, using Faslodex 250mg – 02 ampoules and Zometa (bisphosphonate). Results: With a extraction history performed during the use of bisphosphonate, and with a removable upper and lower total dental prosthesis, attended the Dental Service of aforementioned Oncology Center, presenting bone exposure in the anterior mandible region and complaining of local pain. After clinical and radiographic evaluation, the diagnosis of osteonecrosis was confirmed, characterized by necrosis, pain and bone infection. Considering the mandibular clinical and radiographic condition, and the oncological condition, the Oral Care’s Standard Operational Protocol for Osteonecrosis was initiated, adapted from the Dentistry Service of the National Cancer Institute, but without the Low Power Laser. After 4 months, clinical improvement was noted and the absence of painful symptoms was reported. In addition, it follows the Oral Care Protocol and is being followed up at the aforementioned specialized Service. Conclusion: Invasive surgical procedures and local trauma should be avoided during therapy with bisphosphonates, as they can favor the development of osteonecrosis, in individuals who don’t have oral metastasis and have never undergone radiotherapy in the jaws.

  • Population Structure of the Macroalgae in the Reef Plateau of Piedade Beach (Jaboatão Dos Guararapes-PE)

    Objective: This work analyzes the structure of macroalgae populations on the reef plateau of Praia de Piedade (08º 10 ’S and 34º 56’W), south coast of Pernambuco state. Methodology: The Relevés method was used. Collections were carried out from January to March and May to July 2005 at stations E1 and E2, in the region between tides. Results: The following parameters were observed: the total number of species (T), the covering of each taxon (Ri), total covering (Rt), diversity (H ‘) and equitability (J). 56 infrageneric taxon were identified, being 31 Rhodophyta, 7 Ochrophyta and 18 Chlorophyta. The total coverage varied between 25.58% at station E2 in June and 85.54% at station E1 in July. The diversity varied from 1.74 to 2.7 bits.cel-¹ in the two periods. Conclusion: These results demonstrate that the macroalgae populations on the reef plateau have medium diversity and are formed by fouling, erect and epiphytic strata.

  • Overview on Physical Violence Against Women Between 2009 and 2018 in Brazil

    Objectives: To determine the existence of a pattern of women most frequently victims of physical violence in Brazil over a period of 10 years. Methods: Data from the DATASUS platform were collected on the records of domestic, sexual and other violence, registered by physical violence against female persons between 2009 and 2018. Data from the Violence and Accident Surveillance System on characteristics of the violent act against women were also collected. The Brazilian Institute of Geography and Statistics was also used to collect data from the National Household Sample Survey (PNAD). For bibliographic reference, the descriptors “Domestic and Sexual Violence against Women”, “Domestic Violence” and “Domestic Violence” were searched on virtual data basis and Brazilian articles that were published within the period of the present study were included. Results: There is a continuous and rapid increase in the first half of the study period, with a slight deceleration between 2014 and 2016, followed by a new jump in records from 2017. As for race, the largest numbers are white women, 348428, and browns, 308902. Black women represent 68.25% of the total records of domestic, sexual and other violence, with 8.3% of the total records of physical violence. Conclusion: It is possible to estimate that black women are not making complaints or possibly are not being seen with due care to make them. As it is data that depends on denunciation, which is often not carried out, the results need consideration regarding assertiveness and reflection of reality.

  • TREATMENT OF SPOROTRICOSE IN THE WORLD, WITH EMPHASIS IN BRAZIL: WHAT’S NEW?

    Objective: To evaluate the in vitro and in vivo results of works already published on the use of traditional and alternative medicines in the treatment of sporotrichosis, both in humans and in animals. Methods: The bibliographic research was developed from the analysis of publications found in the scientific literature, with emphasis mainly on Brazil in the period from 2015 to 2020. Updated bibliographies of the medical and veterinary literature were available on MEDLINE, through PubMed, Science direct, Scielo and academic Google, with a total of 28 studies that met the specific work requirements. Results: From the analysis of the reviewed papers, conventional treatments, mainly the use of itraconazole, Amphotericin B and Terbinafine, showed good results in the studies. In addition, the use of alternative treatments, either as the main treatment or support, against sporotrichosis, have shown promise in vitro results, requiring more tests for a possible alternative treatment in the future. Conclusion: The use of alternative treatments is important, since they can be effective against sporotrichosis, becoming a viable means when the animal is resistant to conventional methods.

  • PHARMACEUTICAL ATTENTION IN THE CELIAC DISEASE: SAMPLINGS IN THE CITY OF FOZ DO IGUAÇU/PR

    Objective: To analyze the difficulty found in the diagnosis of celiac disease; the identification of patients’ knowledge about the pathology; Self-medication to treat the symptoms before the disease is detected; the significance of the pharmaceutical care to the celiac patients, among others related problems. Methods: Biographical survey and gathering of data encompassing the sampling of individuals of Foz do Iguaçu, members of the local celiac society. Due to the COVID-19 pandemic, the interviews occurred by electronic contact, trough “Google Forms”. This work had its project submitted to the Research Ethics Committee of UNIOESTE, approved on August 7, 2020 in all of its terms and proposals, with opinion n. 4.198.688. Results: It was found that, of the 180 interviewed, 56.7% of all the carriers made used self-medication. And 41, 1% of all patients reported that the necessary time for the disease diagnosis was 1 to 5 years. Among the most common symptoms was abdominal swelling with 94,4% incidence, cramps with 60,6% and flatulence with 76,1%. Another important factor to be considered is that 87,8% reported to have the pathology under study, due to genetic predisposition. Conclusion: Such responses prove the importance of the pharmaceutical professional to identify the pathology and guide about which conduct must be followed by the patient, as well how to guide them on the possible presence of gluten in some medications, aiming to avoid self-medication, abuse of drugs that can aggravate the symptoms and a greater incentive to clinical knowledge in order to obtain an early diagnosis.

  • ASPERGILLOSIS AND ADVANCES IN ITS TREATMENT IN THE LAST DECADE: A LITERATURE REVIEW

    Introduction: Invasive aspergillosis (AI) remains a fatal infection and difficult to treat in immunocompromised patients. Standard treatment is insufficient for these patients, often impairing their quality of life due to adverse effects, in addition to the short duration. Although mortality rates in patients with UA have decreased in the past two decades with the replacement of amphotericin B deoxycholate (AmB-D) with voriconazole as the first choice, treatment remains sub-ideal for patients due to adverse events and drug interactions with immunosuppressive drugs. Objective: This study aims to carry out a literary review about the scientific productions that address the treatment of AI published in the last 10 years, comparing the success and effectiveness rates of the treatments. Methodology: Through a literature review using the base dates PubMed, Lilacs and MedLine, accepting only articles published in the period 2010 to 2020, and only those in Portuguese or English, with 23 articles selected, of which 7 were included in this review. Results and discussion: There was a prevalence of treatments with voriconazole, used in six of the seven studies reviewed, in addition to being part of the standard Brazilian treatment. Studies related to the treatment of UA are heterogeneous, making it difficult to compare effectively between publications. Well-designed controlled, randomized and multicenter clinical trials are needed to adequately address the issue of the usefulness of the approaches used in Brazil. In addition, combined therapies come in many different forms, requiring cumulative evidence to support the use of combined antifungal therapy in AI, as they are still conflicting and of moderate strength.

  • THE USE OF ANTIPARASITIC DRUGS AS A TREATMENT FOR COVID-19: A NARRATIVE REVIEW

    Objetive: Describe research related to the use of antiparasitic drugs as likely treatment in COVID-19 based on scientific literature. Methods: This is a literature review that uses two platforms as a database: Pubmed and BIREME. Were included in this study twelve published articles, from 2019 to September 2020, which referred to or were related to the use of antiparasitic drugs as a therapeutic alternative to COVID-19. Results: The antiparasitic drugs ivermectin, hydroxychloroquine (HQC), and nitazoxanide (NTZ) were the main drugs extensively studied as therapeutic alternatives for SARS-CoV-2. Ivermectin exhibited a 5000-fold reduction in SARS-CoV-2 RNA over a 48h period, at a concentration of 5μM. While HQC was able to block the entry of SARS-Cov-2 into Vero cells previously treated with 50μM. In addition, NTZ, presented an average inhibition concentration (EC50) of 2.12 μM. The mechanisms of anti-SARS-CoV-2 actions of all the drugs mentioned are not yet fully elucidated. However, it is known that the antiviral potential may be related to the inhibition of essential viral proteins (ivermectin), blockade of interaction in virus-host (HTZ), and immunosuppressant (NTZ). Conclusion: The use of antiparasitic agents for the treatment of SARS-CoV-2 have shown promise. However, it is necessary to further investigate the efficacy of the drugs mentioned in this study, to obtain more satisfactory results, seeking to avoid adverse effects on patients, and ensuring safety for them.

  • ENVIRONMENTAL ENRICHMENT REDUCES CORTICAL EXCITABILITY IN RATS SUBMITTED TO STATUS EPILEPTICUS IN THE PILOCARPINE MODEL: AN EVALUATION FROM CORTICAL SPREADING DEPRESSION

    Objective: This study verified if the exposure to environmental enrichment (EE) influences brain excitability, evaluated by cortical spreading depression (CSD), in rats submitted to status epilepticus (SE). Methods: At 35 days of age, male Wistar rats were divided into two experimental groups: pilocarpine (PILO), which received a single dose of pilocarpine hydrochloride to induce SE, and saline (SAL), which were the group control. On the following day, half of the animals in each group were exposed to EE; while the other half was kept in the standard environment (S), considered control. At 67 days of age, the rats were anesthetized and submitted to CSD. Results: Pilocarpine, isolated, reduced the speed of propagation and increased the duration and amplitude of CSD. EE, itself, reduced the speed of propagation and duration, but increased the amplitude of CSD. In the animals exposed to EE that undergone SE, the values of CSD parameters became closer to the control group. Conclusion: Our results indicate that EE reduced the cortical excitability induced by SE, possibly by promoting antioxidant effects at the brain level, inducing neurogenesis and/or improving the excitatory/inhibitory balance of neurotransmitters.