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    Amburana cearensis is a medicinal species popularly known as “cherry” or “aroma amburana” that has wide distribution in South America, being characteristic of Seasonal Forests. It also occurs in Semideciduous Seasonal Forest, restricted to rocky or limestone outcrops; in Submontane Deciduous SubmontanaSeasonalForest; in Dense Ombrophilous Forest (Atlantic Forest) and even in caatinga/dry forest. Taking into account the growing interest in the search for agents that act in the face of oxidative stress, without causing toxic effects to biological systems, the present study aimed to investigate the phytochemical composition and evaluate the antioxidant and hemotoxic activities in vitro of the aqueous extract obtained from the shells of Amburana cearensis (EAAc). Hemaglutination wasevaluated for human erythrocytes collected from people with the presence of O+ blood. In the face of the tests, Amburana cearensis presented significant results for antioxidant activity without causing erythrocyte hemolysis, highlighting the importance of the species as a source of antioxidant agents, which are recognized for blocking the evolution and acting to combat symptoms triggered by diseases associated with oxidative stress.

  • Evaluation of the Antioxidant Potential of Artisanal Liqueurs Produced From Fruits of the Caatinga Biome

    Plant extraction is a common practice performed in community with the presence of native species with strong population interest. For many Brazilian regions, extractivism acts as a complement of income for the population. The present work aimed to evaluate artisanal liqueurs produced in local communities of the State of Pernambuco in order to observe the antioxidant potentials present during production stages. For this, trials were performed with dpph and abts radicals. All the liqueurs evaluated showed antioxidant potential, with expressive results through the sequestration of the DPPH radical, comprising values of 50 CI between 0.5 and 2.25.

  • Constructing Consumers’ Mental Model with ZMET for Online Foreign Language Learning Activities

    The customers’ particular perception of any product, service, or even brand is also the representation of mental models that underlie the customers’ feelings additionally to consequently account for customer behaviour. To amass such customer insight, this article uses a vital customer analysis tool—the Zaltman metaphor elicitation technique (ZMET) to urge the perceptual and ideal meaning of customers in thinking levels that are different through visual picture and metaphor imagination, along with further incorporate the mean – end chain theory to produce the incorporated mental map for a team of consumers within the context of online language learning, therefore offering better insight into customers behaviour.

  • Incidentally Detected Microscopic Gastrointestinal Stromal Tumor: Clinicopathological and Immunohistochemical Evaluation of 11 Cases

    Aim: Gastrointestinal stromal tumor (GIST) originating from interstitial Cajal cells is the most common mesenchymal tumor of the gastrointestinal tract, often located in the stomach, but can be seen anywhere in the gastrointestinal tract. In this study, microGISTs, a preclinical form of GIST; retrospective evaluation was aimed with clinical, histopathological and immunohistochemical findings. Materials and Methods: This study included 11 cases who underwent surgery in our hospital between 2005 and 2017, were diagnosed as microGIST. Results: Three of the cases included in the study were male (27%), eight were female (73%), and the mean age was 59 years. The average lesion diameter was 0,7 cm. All lesions are asymptomatic and detected during surgeries for other reasons. In eight of 11 cases, the lesion was located in the stomach (73%) and three of them in the small intestine (27%). Mitotic activity was observed in only two cases. Spindle cell morphology was detected in all of them. While five of the cases were determined as dedifferentiated (45%), four of them were differentiated by muscle (36%), two of them were differentiated by nerve (19%). There was no risk of progressive disease in any case. In all cases, tumor cells were diffuse positive with CD117 and DOG1 in the immunohistochemical study. Conclusion: MicroGISTs are clinically different and have a pathologically significant low proliferative capacity than other similar tumors. These tumors with benign behavior potential should be kept in mind in the differential diagnosis of spindle cell mesenchymal lesions in the gastrointestinal tract.


    Introduction: In Brazil it is estimated that there will be 12,500 new cases of cancer in children and adolescents (up to 19 years). It is considered the second cause of death in the kids and adolescents population,for allregions of Brazil, according to the National Cancer Institute (INCA). Even with advances in medicine and a significant increase of about 70% in the survival rate of patients, cancer is still associated with death, pain, loss and suffering, bringing family, personal and social repercussions to patients and families. Objective: This study aimed to identify the importance of religiosity and spirituality as a coping mechanism used by caregivers in relation to the diagnosis of childhood and juvenile cancer. Method: Qualitative descriptive study. Approved by the CEP of the Institute of Integral Medicine Prof. Fernando Figueira – IMIP, with CAAE 10829312.0.0000.5201. Participants were 10 caregivers of patients under going treatment at a pediatric oncolog yunitat a reference hospital in the cityof Recife / PE. Results and discussion: The reports showed the relevance of spirituality as an emotional support to caregivers, a source of Faith and hope in understanding the coping strategy used, in the face of pain, anguish and uncertainty experienced in the search for re – signification and understanding of cancer and its treatment. Conclusion: Considering the importance of the caregiver as essential in the patient’s coping with the disease and treatment, it is concluded that he experiences stress with the impact of diagnosis, seeking in religion and spirituality, an attempt to develop healthier ways of dealing with the suffering and confrontation of children and adolescentes cancer.


    Introduction: Spirituality in the context of illness is used as a coping mechanism by patients, family members and health professionals; allowing the creation of meanings and assisting in the subjectivation of individuals from contents transcendent to life. Objectives: Understand how spirituality is expressed as a coping mechanism in the face of the routine of health professionals working in the pediatric oncology context in the care setting palliative. Methodology: Qualitative study performed in a hospital-school in the city of Recife, a reference in the pediatric oncology treatment. Data collection was performed with 12 health professionals between August and October 2017. Data were collected through sociodemographic questionnaires and individual semi-structured interviews, recorded in audio and subsequently submitted to the Content Analysis technique. Results and Discussion: Spirituality was the coping mechanism most reported by health professionals. Participants meant working in pediatric oncology from the will of God, as chosen people for that mission, relating to the understanding of having a purpose for it. Regarding the practice of the profession before the patients in the process of treatment and palliation, spirituality is understood as the way to deal with the innumerable losses and deaths in the hospital setting. Conclusions/considerations: The presence of spirituality promotes quality of life and helps professionals to make the environment less difficult and endowed with transcendental meanings, showing that they also need the means to give meaning to the suffering present in their daily work.


    Introduction: Moebius syndrome is a rare congenital neurological disease of unknown etiology, that involves several cranial nerves. The main clinical characteristic of this syndrome is the “mask-like face”, that is, the absence of facial expression in situations of sorrow or joy. Objective: This study aims to describe the characteristics of Moebius syndrome and its main implications for dentistry. Methodology: In this study, a literature review was carried out, with searches in the following databases:, pubmed and medline. Furthermore, eight articles were selected, among which three were literature reviews and five were reports of clinical cases. Results: In addition to the genetic relation of the syndrome, there are factors that lead to this disorder, such as the use of misoprostol during pregnancy, for example. Conclusion: Early care for patients with Moebius syndrome by a multidisciplinary team is extremely important, since it will attenuate the effects of this pathology.


    Introduction: To review several studies and reports regarding the causes, diagnoses and characteristics of the study and development of Hutchinson-Gilford Syndrome (HGPS) or progéria. Methodology: Through articles found in the following databases: PubMed Central, Scielo, BVS, Bireme, Scientific Electronic Library Online. Discussion: The approach follows from its genetic origin to its progressive stage of incurable aging along with Therapeutic Strategies for greater well-being and longevity for the patient, in the search to minimize the various pathologies that are submitted throughout their life, trying to increase their expectation average of 13.6 years. Conclusion: Because it is a rare and incurable disease, only palliative treatments for this syndrome are found.

  • Positive Effect of Injectable Platelet Rich Fibrin (i-PRF) on Vital Bone Formation in Graft Reconstruction of the Mandible: A Histologic and Histomorphometric Study

    In this clinical case series, relative centrifugation force (RCF) and centrifugation time (CT) were reduced to produce the liquid form of platelet rich fibrin (i-PRF). The goal of this study is to histologically evaluate if the liquid form of PRF has a positive effect on vital bone formation in the grafted mandible using mineralized freeze-dried allogeneic bone. Materials and Methods: Forty-two patients completed immediate bone grafting after a non-restorable endodontically treated molar tooth was extracted in preparation for future implant surgery. Each bone graft was augmented with i-PRF. To process i-PRF, relative centrifugation force (RCF) was reduced from 2,700 RPM to 700 RPM (60g). Centrifugation time was reduced from 12 minutes to 3 minutes. After an average bone graft healing time of 8 to 12 weeks, bone core samples were obtained at the time of implant surgery for histological and histomorphometric analysis. Results: Forty-two bone cores were harvested at the time of implant surgery for histological and histomorphometric analysis. The liquid form of PRF resulted in greater percentages of vital bone formation (average 87.4 %) compared to the existing published literature. Conclusion: i-PRF resulted in greater percentages of new vital bone formation compared to the published literature. This could be due to the continuous slow release and delivery of growth factors in i-PRF. Further clinical use of iPRF is needed to evaluate the full potential of bone regeneration.

  • In-Vitro Starch Hydrolysis and Prediction of Glycaemic Indices of Biscuits Produced from Wheat, African Walnut and Moringa Seed Flour Blends

    African walnut and moringa seed were procured and processed into flours. Biscuits were thus produced from different blends of wheat flour (WHF), African walnut flour (AWF) and moringa seed flour (MSF) in the ratios of (WHT:AWF:MSF) 100:0:0, 77.5:20:2.5, 75:20:5, 72.5:20:7.5, 70:20:10, 90:0:10, 80:20:0 and labelled from A to G, respectively. The produced biscuits were evaluated for dietary fibre content, in-vitro starch hydrolysis and predicted glycaemic indices. The results of dietary fibre content of the biscuits revealed that sample E was significantly higher with a value of 0.72g compare to other samples. Dietary fibre content of the biscuits increased as the level of substitution with moringa seed flour increased. Results of the in-vitro starch hydrolysis of the biscuits showed that the percentage starch hydrolysed reached its peak at 120 min of digestion and after which, a reduction steps in as digestion time increases. Equilibrium concentration, hydrolysis index and predicted glycaemic indices of the biscuits reduced as the level of substitution of moringa seed flour increased. It revealed sample E with Equilibrium concentration value of 48.06, hydrolysis index of 51.66% and predicted glycaemic index of 68.07. Thus, the blends of 70:20:10 (WHT:AWF:MSF) which represented sample E could be used as medium glycaemic index food.