American Journal of Surgical Research and Reviews


TRANSLATIONAL MEDICINE AND AUTOLOGOUS FAT TRANSFER: FROM BENCH TO BEDSIDE. REGENERATIVE AND PROLIFERATIVE POTENTIAL OF ADIPOSE TISSUE

Research Article of American Journal of Surgical Research and Reviews Translational Medicine and Autologous Fat Transfer: From bench to bedside. Regenerative and proliferative potential of adipose tissue Andrea Edoardo Bianchi, MD1,2, Antonio Lucchi, MD1, Riccardo Luoni Orsi, DMD1, Luigi Clauser, MD1 1Unit of Maxillo-Facial Surgery, Istituto Stomatologico Italiano, Via Pace, 21, 20122 MILANO, Italy; 2University UniCamillus, Via di Sant’Alessandro, 8, 00131 ROME, Italy Aim: Autologous fat transfer (AFT) for the correction of maxillofacial defects was first reported at the end of the 19th century. AFT was introduced as a way of improving facial esthetics and in the last few years has expanded into applications in craniomaxillofacial reconstructive surgery and regenerative therapy. This protocol is part of translational medicine. The aim of translational medicine, or translational science, is to combine disciplines, resources, expertise, and techniques based on three main pillars: bench, bedside, and community. The primary goals to coalesce assets of various natures to significantly improve the global healthcare system. AFT is thus part of translational medicine in tissue healing, regeneration and augmentation. Methods: Several techniques have been suggested for harvesting and grafting the fat. The Authors follow Coleman’s technique with centrifugation and infiltration using different types and sizes of cannulas. Conclusion: This review provides a fairly comprehensive summary of the many exciting possibilities that exist in the field of facial fat grafting. Five clinical cases are presented and discussed. Translational medicine is the basis of this new reconstructive and regenerative field of science and research. Keywords: Regenerative medicine, translational medicine, lipofilling, fat grafting, adipose-derived-stem-cells, fat graft survival, fat graft processing, maxillofacial surgery, soft tissue reconstruction, stem cells, bench to bedside ...

SINGLE STITCH OPEN INTERVAL APPENDECTOMY; WHEN AND WHY

Case Report of American Journal of Surgical Research and Reviews Single stitch Open interval appendectomy; when and why Dr.jitendra kumar Saroj1, Dr santosh Gautam2 1Assistant professor, Department of general surgery Venkateshwara institute of medical sciences, Gajraula, INDIA; 2Assistant professor, Department of general surgery, Prasad institute of medical sciences,Sarojani Nagar Lucknow, Santosh Gautam Appendicitis is a very common cause of acute abdomen. Most of the patient admit in surgical emergency. Diagnosis usually made clinically, sonography sometimes may be helpful. Regarding management there is still controversy exists. Developed country usually performed laparoscopy appendectomy while in developing country surgical management is still in debate. Different surgeons have different opinion either emergency open or laparoscopy appendectomy or interval appendectomy. Even in open appendectomy there is still debate between classical procedure vs small incision. This study favors single stitch surgery rather than classical and laparoscopy appendectomy. this case study supports even better cosmetic and outcome than laparoscopy appendectomy. Keywords: single stitch, interval appendectomy, classical, laparoscopic ...

BLUE ROUND SMALL CELL TUMOR: A SURGICAL UPDATE OF DSRCT WITH REVIEW OF LITERATURE ‘A GRIM AFFAIR’

Research Article of American Journal of Surgical Research and Reviews Blue Round Small Cell tumor: A Surgical Update of DSRCT with review of literature ‘A Grim Affair’ Dr.UwaisRiazUlHasan3 M.Med, Dr.Khathija Hasan M.Med, Dr.Farooq Ahmed Qureshi MS, Dr. Victor Effiong Obong M.B.B.Ch, MWACS, Dr.Abdul Aziz Al Nami M.B.B.S, Dr.Ali Ibrahim AlShaqaqiq M.B.B.S, Dr.Mohammad AbdulMajeed Alghadeer M.B.B.S Dr. Marwan Ahmad AlRayhan M.B.B.S, Dr. Mohammed Ali AlJummah M.B.B.S, Dr.Baqer Ali Aldheen M.B.B.S, Dr. Ali Hussain AlRufayi MD, Dr.ShehlaRiazUlHasan Phd. Dr. Moath AbdulAziz AlMasoud2 M.D, Dr. Noura Al Dossary1 Department of General Surgery, Al Omran General Hospital, Al Hassa, Kingdom of Saudi Arabia. Hospital Director1,Head of department2, Assoc Consultant General Surgeon3 Desmoplastic small round cell tumor (DSRCT) is a tumor derived from the Greek desmos referring to knot and plasis to formation an uncommon soft tissue malignant tumor, mesenchymal in origin and aggressive with a prelidiction for males and advanced at presentation. It was first described as a distinct clinical entity by Gerald WL and Rosai J (7). There are fewer than 200 reported to date. Depending on the primary site of location the Clinical manifestations vary. As most arise from the abdomen and pelvis they remain asymptomatic till they attain a huge size. Other reported sites are the skull, thorax, and paratesticular region (10,13). We report the case of a 19 yr old male who had non specific abdominal discomfort with asthenia for a period of six months and was referred to us for evaluation of left supraclavicular nodes. The prognosis of Desmoplastic small round cell tumor (DSRCT) is poor with few surviving less than two years. Keywords: Blue round, Desmoplastic small round cell tumor, Radiology, Multimodal therapy ...

TREATMENT OF “EN COUPE DE SABRE “ LINEAR SCLERODERMA. SOFT TISSUE AUGMENTATION AND REGENERATION BY AUTOLOGOUS FAT TRANSFER

Research Article of American Journal of Surgical Research and Reviews Treatment of “En Coupe De Sabre “ Linear Scleroderma. Soft Tissue Augmentation and Regeneration by Autologous Fat Transfer Luigi Clauser,MD1, Antonio Lucchi,MD1, Carolina Sannino,MD1, and Andrea Edoardo Bianchi,MD1, 2 1Unit of Maxillo-Facial Surgery, Istituto Stomatologico Italiano, Via Pace, 21, 20122 Milano, Italy; 2 University UniCamillus ,Via di Sant’Alessandro,8,00131 Roma,Italy Aim: Frontal linear scleroderma, also known as ‘‘en coup de sabre,’’ is a congenital deformity characterized by atrophy and furrowing of the skin of the front parietal area above the level of the eyebrows. In most cases it occurs as a single paramedian line that may be associated with hypoplasia of underlying structures and facial hemiatrophy. In case of a wide lesion many reconstructive strategies have been proposed. The modern approach is aimed at augmentation of the tissue deficiency by using lipostructure and tissue regeneration. Autologous  fat transfer (AFT) seems to be an effective strategy to restore the normal volume and contour of the face while providing a source of adipose-derived stem cells (ADSCs) with a multilineage differentiation potential. Methods: In this report, we present a rare case of linear scleroderma en coupe de sabre which was successfully managed with three stages of  autologous fat grafting. Conclusion: The proposed uses for ADSCs in tissue repair and regeneration are quite impressive. Recent works on ADSCs would suggest that adult cells may prove to be an equally powerful regenerative tool in treating congenital and acquired maxillofacial disorders. More importantly, physicians, researchers and international associations need to cooperate in informing clinicians about what practices are based on evidence  and to encourage support of additional research. There is increasing interest in a possible therapeutic effect of ADSCs from processed lipoaspirate for a wide spectrum of clinical applications in the facial and craniofacial area. AFT can ...

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American Journal of Surgical Research and Reviews

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